(1):
(a.) Physical pain, or a cause of it; malady.
(2):
(a.) Pain of mind on account of something in the past; mental suffering arising from any cause, as misfortune, loss of friends, misconduct of one's self or others, etc.; sorrow; sadness.
(3):
(a.) Cause of sorrow or pain; that which afficts or distresses; trial; grievance.