(1):
(n.) An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
(2):
(n.) Malice; malignity; spite; malicious anger; contemptuous hate.
(3):
(n.) To vex; to annoy; to offend contemptuously.
(4):
(prep.) In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.