Tiglath-pileser (tĭg'lath-pĭ-lç'zer). The second Assyrian king mentioned in the Scriptures as having come into contact with the Israelites, and the second of the name. He invaded Samaria, 2 Kings 15:29, and after some years destroyed Damascus, taking many captives. 1 Chronicles 5:26. The occasion of the first attack was probably the refusal of Pekah to pay tribute; of the second, the call of Ahaz upon him for assistance against Pekah and Rezin, the king of Syria, Tiglath-pileser at Damascus met Ahaz, who became his vassal. 2 Kings 16:10. He reigned b.c. 747-730.